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New published article in Scientific Data

I am happy to inform you that our last paper entitled “Characterization of hormone-producing cell types in the teleost pituitary gland using single-cell RNA-seq” has just been published in Scientific Data.

This paper mainly made by our PhD candidate Khadeeja Siddique and its supervisor Dr Christiaan Henkel, describes the transcription profile of male and female medaka pituitary at the single cell level.

This work has been used as a basis for the already published work on the 3D atlas pituitary of the model medaka. The data from these single cell RNA-sequencing are also available on the atlas website.

Abstract: The pituitary is the vertebrate endocrine gland responsible for the production and secretion of several essential peptide hormones. These, in turn, control many aspects of an animal’s physiology and development, including growth, reproduction, homeostasis, metabolism, and stress responses. In teleost fish, each hormone is presumably produced by a specific cell type. However, key details on the regulation of, and communication between these cell types remain to be resolved. We have therefore used single-cell sequencing to generate gene expression profiles for 2592 and 3804 individual cells from the pituitaries of female and male adult medaka (Oryzias latipes), respectively. Based on expression profile clustering, we define 15 and 16 distinct cell types in the female and male pituitary, respectively, of which ten are involved in the production of a single peptide hormone. Collectively, our data provide a high-quality reference for studies on pituitary biology and the regulation of hormone production, both in fish and in vertebrates in general.

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